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perpetual change caused by karma; vicissitudes of life; that which is made
「有為」 has another reading with different meanings.
有為な人材を育成することが大学の使命だ。
It is the university's mission to nurture talented individuals.
有為転変の世にあって心の平安を求めた。
In this world of constant change, they sought peace of mind.
有為の若者が社会改革に立ち上がった。
Promising young people rose up for social reform.