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in a big way; in a large way; on a grand scale; wide; extensively
試合の結果が大きく変わる可能性がある。
There is a possibility that the match result will change significantly.
彼女は目を大きく見開いて驚いた。
She opened her eyes wide in surprise.
計画を大きく見直す必要がある。
We need to significantly revise the plan.