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unable to do (as one wishes); able to do only with great effort; almost impossible to do; beyond one's control; not always turning out as one wishes; not going the way one wants it to
思い通りにままならないこともある。
There are times when things do not go as we wish.
体調がままならない日々が続いていた。
Days when my health was not under control continued.
自由にままならない生活は辛いものだ。
A life where one cannot do as one wishes is hard.