Fetching details from the dictionary...

sacrifice
victim (esp. someone killed); casualty
sacrifice (to a deity)
家族を犠牲にしてまで仕事に打ち込むべきか悩む。
I wonder if I should devote myself to work at the expense of my family.
睡眠時間を犠牲にして働きました。
I worked sacrificing sleep time.
神への犠牲として羊を捧げました。
A sheep was offered as a sacrifice to the gods.