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the times; the world; society
この御時世、物価が高い。
In these times, prices are high.
この御時世、在宅勤務が普通になった。
In this day and age, working from home has become normal.
この御時世だから、小さい店は生き残るのが大変だ。
Because of the current times, it's hard for small shops to survive.