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worsening; deterioration; exacerbation; aggravation (of a disease)
薬の服用を中断したため症状が増悪した。
Symptoms worsened because the medication was discontinued.
感染症の増悪を防ぐために早期治療が必要だ。
Early treatment is necessary to prevent the worsening of an infection.
病状が増悪し緊急手術が行われた。
The condition worsened and emergency surgery was performed.