to torment; to pain; to inflict (physical) pain; to hurt
to harass; to cause (emotional) pain; to afflict; to distress; to bother; to trouble; to stump; to baffle
長い病気が彼を苦しめた。
A long illness tormented him.
借金が家計を苦しめている。
Debt is burdening the household finances.
異常気象が世界中の農家を苦しめる事態になった。
Abnormal weather has become a situation tormenting farmers around the world.