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sincerely; earnestly; wholeheartedly
repeatedly; over and over; again and again
くれぐれも体に気をつけてください。
Please take good care of yourself.
呉れ呉れも注意するように言われた。
I was told over and over to be careful.
くれぐれも道中ご安全に。
Please do take care on your journey.