Fetching details from the dictionary...
humour; humor; temper; mood; spirits
safety; health; well-being; one's situation
in a good mood; in high spirits; happy; cheery; merry; chipper
今日は御機嫌がいいですね。
You're in a good mood today.
上司の御機嫌を伺うのは疲れる。
It's tiring to gauge the boss's mood.
子供が御機嫌斜めで何をしても泣いている。
The child is in a bad mood and cries no matter what.