obstacle; hindrance; impediment; difficulty
雨で電車が遅れて、会議に支障が出ました。
The train was delayed due to rain, which caused problems for the meeting.
風邪をひいて、仕事に支障をきたしています。
I caught a cold and it's interfering with my work.
この故障は日常生活に支障はありません。
This malfunction doesn't cause any hindrance to daily life.