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beginning; start; first step
clue; lead; hint
thread end
「緒」 has other readings with different meanings.
解決の糸口が見えてきた。
A clue to the solution has come into view.
事件の糸口をつかむまでに時間がかかった。
It took time to find a lead in the case.
彼の一言が問題解決の糸口になった。
His remark became the starting point for solving the problem.