Fetching details from the dictionary...

thing; matter
incident; occurrence; event; something serious; trouble; crisis
circumstances; situation; state of affairs
work; business; affair
after an inflectable word, creates a noun phrase indicating something the speaker does not feel close to
nominalizing suffix
pretending to ...; playing make-believe ...
alias; also known as; otherwise known as; or
necessity; need
you should ...; I advise that you ...; it's important to ...
「事」 has other readings with different meanings.
今日は大切な事があるので早く帰ります。
There's an important matter.
そんな事は絶対にありえません。
There's no such thing.
今日は嬉しい事がたくさんありました。
A good thing happened.