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to grapple with; to wrestle with; to engage in a bout; to be matched against
to tackle (e.g. a problem); to come to grips with; to work hard on
環境問題に真剣に取組む自治体が増えている。
More and more local governments are seriously tackling environmental issues.
研究チームは難病の治療法開発に取組んでいる。
The research team is working on developing treatments for intractable diseases.
新しい課題に前向きに取組む姿勢が評価された。
His positive attitude toward tackling new challenges was highly regarded.