to manage (all by oneself); to control; to run; to take charge of
彼が式の進行を取り仕切った。
He managed all the ceremony proceedings.
父は長年にわたってこの会社を取り仕切っている。
My father has run this company for many years.
一人で全部は取り仕切れない。
I can't manage everything on my own.