after all; in the end; anyway
(cannot) possibly; (not) at all; (not) by any means; (not) ever
所詮、彼は敗者だ。
After all, he is a loser.
所詮、時間の無駄だった。
It was a waste of time after all.
所詮、個人の努力には限界がある。
After all, there are limits to individual effort.