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to operate (e.g. a machine); to handle; to manage; to control; to maneuver; to steer
to have a good command of (a language); to play proficiently (of a musical instrument)
to work (a puppet); to pull the strings of a puppet
to manipulate (a person, public opinion, etc.); to pull the strings; to control from the shadows; to mastermind
父は趣味でラジコンヘリを上手に操ります。
My father operates the radio-controlled car skillfully.
経験豊富な船長は大型船を慎重に操っていた。
The captain steered the ship carefully.
言葉巧みに人を操る。
He skillfully manipulates people with words.