Fetching details from the dictionary...

loss; damage; harm; unprofitable
disadvantage; handicap; drawback; unfavorable
この取引は損だと思ったので断った。
I thought this deal was a loss.
損をしても経験になると思う。
Even if I lose, I think it will be an experience.
彼の判断ミスで会社は損を出した。
The company suffered a loss due to his misjudgment.