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to harm; to hurt; to injure; to wreck
to miss one's chance to (do something); to fail to (do what one ought to have done)
無理をして健康を損ねることがある。
Overexertion can harm your health.
あの発言が二人の関係を損ねた。
That remark damaged the relationship between the two.
睡眠不足が彼の健康を損ねている。
Lack of sleep is damaging his health.