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by all means; at any cost; no matter what; at any rate; surely
whether (one is) willing or not; willingly or unwillingly; willy-nilly
on no account; by no means
in the end; in the long run; after all; eventually
どうしても諦められない夢がある。
There's a dream I can't give up no matter what.
どうしても会いたい人がいる。
There's someone I want to see no matter what.
どうしてもうまくいかない時もある。
There are times when things just don't work out.