Fetching details from the dictionary...

by all means; at any cost; no matter what; at any rate; surely
whether (one is) willing or not; willingly or unwillingly; willy-nilly
on no account; by no means
in the end; in the long run; after all; eventually
どうしても行きたい場所がある。
There's a place I want to go no matter what.
彼女はどうしても諦めなかった。
She wouldn't give up no matter what.
どうしても理解できない問題だ。
It's a problem I just can't understand.