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to get tired; to become exhausted; to grow weary
to become worn out; to become battered (from long use)
to get tired of (doing); to get fed up with
長時間歩いてすっかりくたびれた。
I got completely tired from walking for a long time.
仕事でくたびれて何もする気が起きない。
I'm too tired from work to feel like doing anything.
旅行から帰ってくたびれて眠ってしまった。
I came back from the trip tired and fell asleep.