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to stand in the way; to bar someone's way; to block the way
警備員が前に立ち塞がった。
A security guard stood in the way.
彼女の前に立ち塞がって、いじめっ子がお金を要求した。
Standing in her way, the bully demanded her money.
新事業には多くの困難が立ち塞がる。
Many difficulties stand in the way of a new business.