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to begin a trip; to depart; to embark
to die; to pass away; to depart this life
新天地に向けて旅立った。
I departed for a new land.
若者が夢を追って旅立っている。
Young people are departing in pursuit of their dreams.
大学を卒業し、新たな人生へ旅立つ日が来た。
The day came to graduate from university and set off on a new life.