to throb (with pain); to ache; to smart; to twinge
to rankle; to gall; to rile
寒くなると古傷が疼いた。
When it got cold, the old wound ached.
雨の前になると古い怪我が疼いている。
Before it rains, the old injury throbs.
疼いて眠れない夜が続いてやっと病院に行った。
After nights on end unable to sleep from the aching, I finally went to the hospital.