Fetching details from the dictionary...

wound; injury; cut; gash; bruise; scratch; scrape; scar
chip; crack; scratch; nick
flaw; defect; weakness; weak point
stain (on one's reputation); disgrace; dishonor; dishonour
(emotional) hurt; hurt feelings
テーブルについた瑕が気になって仕方がない。
The scratch on the table keeps bothering me.
この宝石には小さな瑕が一つある。
This gemstone has one small flaw.
転んで膝に瑕ができてしまった。
I fell and got a scrape on my knee.