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to cause; to induce; to bring about a result or state; to produce
睡眠不足は体調不良をきたす。
Lack of sleep causes poor health.
信頼関係に支障をきたした。
It caused a problem in the trust relationship.
睡眠不足が体調に支障をきたしている。
Lack of sleep is causing problems with my health.