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hindrance; impediment
差支えなければ、お名前を伺えますか。
If you don't mind, may I ask your name?
業務に差支えが出ないよう調整した。
I made adjustments so it would not interfere with work.
健康に差支えのない範囲で飲酒する。
I drink only to the extent that it won't harm my health.