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to rub; to chafe
to wear out; to become worn
to lose one's innocence; to become sly
「擦れる」 has other readings with different meanings.
靴底が擦れて薄くなってきてしまいました。
The shoe soles have worn thin from rubbing.
彼女は都会暮らしで少し擦れた感じがする。
She seems to have become jaded in the city.
新しい革靴を履いたら踵が擦れた。
My heel got chafed from wearing new leather shoes.