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to go through; to pierce; to penetrate
to run through (e.g. a river through a city); to pass through
to stick to (opinion, principles, etc.); to carry out; to persist with; to keep (e.g. faith); to maintain (e.g. independence)
的に向かって放たれた矢が的を貫いた。
The arrow shot at the target pierced it.
自分の信念を貫いて生きていきたいです。
I want to live while sticking to my beliefs.
彼は最後まで初志を貫き通しました。
He stuck to his original intention until the end.