weariness (from); fatigue; tiredness; exhaustion
「疲れ」 has another reading with different meanings.
tiredness; fatigue
weariness caused by prolonged hot bath
疲れを感じたら無理をしないでね。
Don't overdo it if you feel tired.
目の疲れを和らげるために休憩した。
I took a break to relieve eye fatigue.
長時間の運転で疲れが出てきた。
Fatigue started to set in from long hours of driving.