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(in) the middle of; (in) the midst of; (in) the course of; (at) the height of
「最中」 has another reading with different meanings.
会議の最中に突然電話が鳴った。
The phone rang in the middle of the meeting.
勉強の最中に邪魔をしないで。
Don't disturb me while I'm studying.
食事の最中に話しかけないで。
Don't talk to me while I'm eating.